VIP (Vasoactive Intestinal Peptide)

VIP (Vasoactive Intestinal Peptide) | 28-Amino-Acid Neuropeptide | Research Use Only

VIP, or Vasoactive Intestinal Peptide, is a 28-amino-acid neuropeptide belonging to the secretin/glucagon peptide superfamily. It acts as an agonist at the class B G-protein-coupled receptors VPAC1 and VPAC2 and is broadly distributed throughout the central and peripheral nervous systems. VIP is a well-characterized research tool used to study neuropeptide signaling, vasoactive and smooth-muscle physiology, and neuroimmune communication in laboratory models.

In research settings, VIP is frequently used as a reference agonist in studies of VPAC-receptor pharmacology, circadian regulation within the suprachiasmatic nucleus, and the modulation of inflammatory and immune signaling pathways in vitro and in preclinical models. Its broad receptor activity makes it a valuable probe for investigating class B G-protein-coupled receptor mechanisms.

Research Specifications

• Synonyms: Vasoactive Intestinal Peptide, Vasoactive Intestinal Polypeptide, VIP
• Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
• Molecular Formula: C147H237N43O43S
• Molecular Weight: ~3326.8 g/mol
• CAS Number: 37221-79-7 (PubChem CID 53314964; 40077-57-4 is an alternate registry number for the same peptide)
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: -20°C, protected from light and moisture

Made in the USA from imported peptide APIs (purified, filled and lyophilized domestically) and independently third-party tested. A Certificate of Analysis is published for every shipped lot – look yours up with our COA verification tool.

For Research Use Only. This product is not intended for human or veterinary use, diagnosis, or treatment. Not a drug, supplement, or medical device. Not evaluated by the FDA. For qualified research applications only.

Chemical identity & references
PubChem CID 53314964 · UniProt P01282 (human precursor) · CAS 37221-79-7 · C147H237N43O43S, 3326.8 g/mol

Molecular weights shown are nominal identity values; salt or complex form and net peptide content are stated on each lot’s Certificate of Analysis. Verify this lot’s COA.