TB-500

New to these two? Read BPC-157 and TB-500: What the Blend Actually Contains, covering why “TB-500” is sold as two different molecules and what to check on a blend certificate.

Made in the USA from imported peptide APIs (purified, filled and lyophilized domestically) and independently third-party tested. A Certificate of Analysis is published for every shipped lot, look yours up with our COA verification tool.

TB-500 (Thymosin Beta-4) Synthetic Actin-Sequestering Peptide | Research Use Only

TB-500 is a synthetic analogue of Thymosin Beta-4 (Tβ4), a naturally occurring 43 amino acid peptide ubiquitously expressed in mammalian tissues and found at elevated concentrations at sites of injury and cellular repair. As a primary actin-sequestering peptide, Thymosin Beta-4 plays a fundamental role in cytoskeletal dynamics by binding G-actin monomers and regulating actin polymerization, a mechanism central to cell migration, proliferation, and tissue remodeling processes.

In laboratory and preclinical research models, TB-500 has been investigated across a wide range of biological systems. Research applications include wound healing model studies, angiogenesis and vascular biology investigations, and cardiac tissue repair research in post-injury animal models. It has been extensively studied in connective tissue biology, including tendon, ligament, and muscle repair models, as well as corneal wound healing and hair follicle biology research. Additional research areas include neurological recovery models, anti-inflammatory signaling pathway investigations, and stem cell mobilization studies. TB-500 is widely utilized as a research tool in studies examining extracellular matrix interactions, cell survival mechanisms, and growth factor upregulation.

Research Specifications:

Available in Single 10MG vials or 10 Packs

• Type: Synthetic Thymosin Beta-4 analogue (43 amino acids)
• CAS Number: 77591-33-4
• Molecular Weight: ~4963.5 g/mol
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: -20°C, protected from light and moisture

For Research Use Only. This product is not intended for human or veterinary use, diagnosis, or treatment. Not evaluated by the FDA. For qualified research applications only.

Chemical identity & references
"TB-500" is sold as two distinct molecules. Full-length Thymosin β4: PubChem CID 16132341 · UniProt P62328 · C212H350N56O78S, ~4963 g/mol. Our published TB-500 lot certificates to date (for example DPS-2022011, and the TB-500 pages of the KLOW certificate UMP-4944656) identify full-length thymosin β4, CAS 77591-33-4. Many "TB-500" lots are instead the acetylated N-terminal fragment Ac-LKKTETQ. Confirm which molecule your lot contains on its COA; see our explainer, BPC-157 and TB-500: what the blend actually contains

Molecular weights shown are nominal identity values; salt or complex form and net peptide content are stated on each lot’s Certificate of Analysis. Verify this lot’s COA.