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SS-31, also referenced in the literature as elamipretide or MTP-131, is a synthetic water-soluble tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH2. Its alternating aromatic-cationic structure allows it to concentrate in the inner mitochondrial membrane independently of membrane potential, which is why it is widely used as a reference compound in mitochondrial research.
In laboratory settings, SS-31 is studied for its association with cardiolipin, the signature phospholipid of the inner mitochondrial membrane, and for how that interaction relates to cristae architecture, electron transport chain organization and mitochondrial respiration. It appears frequently in in-vitro and preclinical work on oxidative stress, ATP synthesis and models of mitochondrial dysfunction.
New to this compound? Read What Is SS-31?, a plain-English look at the names, the structure, and what to check on a certificate of analysis.
Made in the USA from imported peptide APIs (purified, filled and lyophilized domestically) and independently third-party tested. A Certificate of Analysis is published for every shipped lot, look yours up with our COA verification tool.
For Research Use Only. This product is not intended for human or veterinary use, diagnosis, or treatment. Not a drug, supplement, or medical device. Not evaluated by the FDA. For qualified research applications only.
Chemical identity & references
PubChem CID 11764719 · CAS 736992-21-5 · C32H49N9O5, 639.8 g/mol
Molecular weights shown are nominal identity values; salt or complex form and net peptide content are stated on each lot’s Certificate of Analysis. Verify this lot’s COA.



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Research Use Only. All products sold by USA Made Peps are intended strictly for laboratory research use by qualified researchers. They are not for human or veterinary use, consumption, ingestion, injection, or any form of in vivo administration. They are not dietary supplements, foods, pharmaceuticals or medical devices, and are not FDA approved to diagnose, treat, cure or prevent any disease or condition. Purchasers must be at least 21 years of age and confirm qualified researcher status at checkout.
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