Melanotan 2

Melanotan II (MT-II) Cyclic Melanocortin Receptor Agonist Analogue | Research Use Only

Melanotan II is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), developed as a more metabolically stable and potent melanocortin receptor agonist. Structural modifications — including cyclization, incorporation of D-phenylalanine, and an acetylated N-terminus — confer resistance to enzymatic degradation and enhanced receptor binding relative to native α-MSH.

Melanotan II acts as a non-selective agonist across multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R, MC5R) and has been extensively utilized in preclinical research examining melanocortin system pharmacology. Research applications include melanogenesis and pigmentation biology studies, hypothalamic MC4R signaling investigations, appetite and energy homeostasis models, cardiovascular biology research, and neuroprotective pathway studies. It serves as a widely used pharmacological tool in studies characterizing melanocortin receptor subtype selectivity and downstream signaling mechanisms.

Research Specifications:

• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
• Molecular Formula: C₅₀H₆₉N₁₅O₉
• Molecular Weight: 1024.2 g/mol
• CAS Number: 121062-08-6
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Storage: -20°C, protected from light and moisture

State Restrictions Notice: Due to state-specific regulations, customers in California and Florida are solely responsible for ensuring compliance with applicable local laws prior to purchase. By completing this transaction, the purchaser confirms they are authorized to receive this research compound in their jurisdiction.

For Research Use Only. This product is not intended for human or veterinary use, diagnosis, or treatment. Not evaluated by the FDA. For qualified research applications only.