KPV

KPV Alpha-MSH C-Terminal Tripeptide | Research Use Only

KPV (Lysine-Proline-Valine) is a naturally derived tripeptide representing the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH). As a bioactive fragment of α-MSH, KPV has been studied for its interactions with melanocortin receptors and its role in downstream anti-inflammatory signaling cascades, demonstrating activity in research models independent of the full α-MSH sequence.

In preclinical and in vitro research, KPV has been investigated for its modulation of NF-κB signaling pathways, pro-inflammatory cytokine expression, and innate immune response mechanisms. It has been utilized in gastrointestinal research models examining intestinal epithelial cell biology, mucosal barrier function, and gut inflammation pathways. Additional research applications include wound healing models, skin biology investigations, and studies examining melanocortin receptor (MC1R, MC3R) pharmacology and downstream signaling.

Research Specifications:

• Sequence: Lys-Pro-Val
• Molecular Formula: C₁₆H₃₀N₄O₄
• Molecular Weight: ~342.4 g/mol
• CAS Number: 13147-19-8
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Storage: -20°C, protected from light and moisture

For Research Use Only. This product is not intended for human or veterinary use, diagnosis, or treatment. Not evaluated by the FDA. For qualified research applications only.